Salmonella bacteria cause over a million infections annually in the United States, primarily through contaminated food consumption, leading to symptoms like diarrhea, fever, and stomach cramps. Children under 4, those not breastfed, and individuals with weakened immune systems are at higher risk. The bacteria spread through various animal products, contaminated water, and contact with infected pets. Recent outbreaks, such as contaminated organic basil, emphasize the importance of proper food handling and hygiene. Symptoms range from gastroenteritis to severe complications like bacteremia and meningitis. Travelers to certain regions may encounter typhoid fever, a potentially fatal strain of Salmonella. Diagnosis involves laboratory testing, while treatment focuses on supportive care, with antibiotics reserved for severe cases. Prevention measures include thorough cooking of food, handwashing, and avoiding contact with reptiles, especially for immunocompromised individuals. Travelers to high-risk areas should consider vaccination.